Surface-Modification Superparamagnetic Nanoparticles for Highly-Efficient Intracellular Hyperthermia

Author

Wang, Xiaowen ; Kan, Sixing ; Zhao, Lingyun ; Tang, Jintian ; Chen, Benke

Author_Institution

Key Lab. of Particle & Radiat. Imaging, Tsinghua Univ., Beijing, China

fYear

2010

fDate

18-20 June 2010

Firstpage

1

Lastpage

5

Abstract

Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) can play crucial roles for medical applications such as cancer magnetic induction hyperthermia, magnetic resonance imaging and magnetofection. Herein we report the results of modified magnetic nanoparticles coated with protamine peptides containing nuclear localization signal sequences. Functionalization of these SPIONs under alternating magnetic field radiation resulted in more cellular uptake and higher-efficient cytotoxicity in HepG2 cells. The work demonstrates that functionalized SPIONs can be used as a novel kind of highly efficient magnetic mediator for magnetic induction intracellular hyperthermia.

Keywords

biomedical materials; biomolecular effects of radiation; cancer; cellular biophysics; cellular effects of radiation; hyperthermia; molecular biophysics; nanobiotechnology; nanoparticles; proteins; cancer magnetic induction hyperthermia; cytotoxicity; magnetic induction intracellular hyperthermia; magnetic resonance imaging; magnetofection; protamine peptides; superparamagnetic iron oxide nanoparticles; superparamagnetic nanoparticles; Biomedical equipment; Cancer; Hyperthermia; Iron; Magnetic fields; Magnetic resonance imaging; Medical services; Nanoparticles; Peptides; Sequences;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Conference_Location

Chengdu

ISSN

2151-7614

Print_ISBN

978-1-4244-4712-1

Electronic_ISBN

2151-7614

Type

conf

DOI

10.1109/ICBBE.2010.5516427

Filename

5516427