Modeling the dynamic composition of engineered tissues

Author

Wilson, Christopher G. ; Kohles, Sean S. ; Bonassar, Lawrence J.

Author_Institution

Dept. of Biomed. Eng., Worcester Polytech. Inst., MA, USA

fYear

2001

fDate

2001

Firstpage

83

Lastpage

84

Abstract

Investigation of the mechanisms underlying scaffold degradation and neotissue synthesis is essential to predicting the mechanical and biological performance of engineered tissues. Modeling the dynamic composition of cell-polymer constructs may be useful in estimating the long-term mechanical performance of the engineered tissue. In this preliminary study, we fit mathematical models of scaffold mass loss and extracellular matrix synthesis to previously published data

Keywords

biological tissues; biomechanics; biomedical materials; cellular biophysics; physiological models; biological performance; cell-polymer constructs; dynamic composition modeling; engineered tissues; extracellular matrix synthesis; long-term mechanical performance; mathematical models; mechanical performance; neotissue synthesis; scaffold degradation; scaffold mass loss; Biodegradable materials; Biological system modeling; Biological tissues; Biomedical engineering; Degradation; Electrochemical machining; Engineering in medicine and biology; Extracellular; Mathematical model; Polymers;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2001. Proceedings of the IEEE 27th Annual Northeast

Conference_Location

Storrs, CT

Print_ISBN

0-7803-6717-0

Type

conf

DOI

10.1109/NEBC.2001.924731

Filename

924731