The Role of Mechanical Stimulation in Engineering of Extracellular Matrix (ECM)

Author

Sebastine, Immanuel M. ; Williams, David J.

Author_Institution

Wolfson Sch. of Mech. & Manuf. Eng., Loughborough Univ.

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

3648

Lastpage

3651

Abstract

The engineering of ECM in vitro is a critical area of research in tissue engineering. Cells respond to mechanical stimuli and regulate the metabolic functions via mechanotransduction and synthesise ECM. This paper reviews key pathways. In vitro studies of mechanotransduction on macroscopic tissues in specialised automated bioreactors that are capable of mimicking the physiological environment by applying different loads will help us to examine how mechanical loads influence intracellular signalling, subsequent behaviour of cells and the synthesis of ECM components

Keywords

biological tissues; bioreactors; cellular biophysics; mechanoception; tissue engineering; ECM; automated bioreactor; extracellular matrix; intracellular signalling; macroscopic tissue; mechanical stimulation; mechanical stimuli; mechanotransduction; metabolic function; tissue engineering; Cities and towns; Electrochemical machining; Extracellular; Gene expression; In vitro; In vivo; Protein engineering; Signal processing; Signal synthesis; Tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260344

Filename

4462588