Carbon Nanopowder Binds with DNA and May Induce DNA Aggregation

Author

Guo, Changlu ; Liu, Qingdai ; Ji, Qiaoli ; An, Hongjie ; Zhang, Zhizhou ; Wang, Yadong

Author_Institution

Res. Center of Bioinformation Technol., Harbin Inst. of Technol., Harbin, China

fYear

2010

fDate

18-20 June 2010

Firstpage

1

Lastpage

3

Abstract

The interaction between nanomaterials and genomes is getting more and more attention. Such studies are getting involved into several fields: environment safety, food safety, nanobiotechnology and drug development. Direct interaction between nanoparticles and DNA in vitro has been reported in several studies, but data for in vivo binding between genomic DNA and nanoparticles are rare. In this study, we presented that carbon nanopowder (CNP) is able to bind with DNA both in vitro and in vivo. Interestingly, CNP binds to DNA with a relatively high density and may induce DNA aggregation.

Keywords

DNA; aggregation; biochemistry; biological techniques; bonds (chemical); carbon; genomics; molecular biophysics; nanobiotechnology; nanoparticles; C; DNA; aggregation; carbon nanopowder; drug development; environment safety; food safety; in vivo binding; nanobiotechnology; nanomaterial-genome interactions; nanoparticles; Bioinformatics; DNA; Drugs; Genomics; In vitro; In vivo; Nanobiotechnology; Nanomaterials; Nanoparticles; Safety;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Conference_Location

Chengdu

ISSN

2151-7614

Print_ISBN

978-1-4244-4712-1

Electronic_ISBN

2151-7614

Type

conf

DOI

10.1109/ICBBE.2010.5517975

Filename

5517975