A semiconductor nanobridge biosensor for electrical detection of DNA hybridization

Author

Parizi, K.B. ; Nishi, Y.

Author_Institution

Electr. Eng. Dept., Stanford Univ., Stanford, CA

fYear

2008

fDate

6-9 Oct. 2008

Firstpage

87

Lastpage

88

Abstract

In this paper, the modeling, fabrication and optimization of the proposed nanobiosensor for detection of biomolecules such as DNA hybridization has been studied and different advantages and disadvantages of such a device are discussed. This paper outlines how the modulation of impedance in a novel silicon nanobridge (nanowire) biosensor can be used in characterizing biochemical species such as a antibodies/antigens or for detection of a particular DNA sequence hybridization. The array of biosensors fabricated from a SOI wafer with the thickness of 50 nm are studied and simulations are carried out using the TCAD simulator (MEDICI) softwares.

Keywords

DNA; biochemistry; bioelectric phenomena; biosensors; electric impedance; elemental semiconductors; molecular biophysics; nanobiotechnology; nanowires; semiconductor device models; semiconductor quantum wires; silicon; silicon-on-insulator; technology CAD (electronics); DNA hybridization; MEDICI software; SOI wafer; Si; TCAD simulator; antibodies; antigens; electrical detection; impedance; nanobiosensor; optimization; semiconductor nanobridge biosensor; silicon nanobridge; silicon nanowire; size 50 nm; Biomedical optical imaging; Biosensors; Conference proceedings; Couplings; DNA; Fabrication; Phase detection; Semiconductor films; Silicon; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

SOI Conference, 2008. SOI. IEEE International

Conference_Location

New Paltz, NY

ISSN

1078-621X

Print_ISBN

978-1-4244-1954-8

Electronic_ISBN

1078-621X

Type

conf

DOI

10.1109/SOI.2008.4656307

Filename

4656307