Vulnerability in a one-dimensional transmural model of human ventricular tissue in heart failure

Author

Kharche, S. ; Holden, A.V. ; Zhang, H.

Author_Institution

Biol. Phys. Group, Manchester Univ.

fYear

2005

fDate

25-28 Sept. 2005

Firstpage

563

Lastpage

566

Abstract

Heart failure (HF) induces remodeling in cellular ionic channel kinetics and calcium handling in the ventricle. In the present study, we investigated the effects of HF on rate dependent electrical activity of human ventricular myocytes by characterizing the dynamic action potential duration restitution (APDr), action potential (AP) alternans, intracellular calcium transient ([Ca²⁺]_i) alternans, and delayed after depolarizations (DADs) AP. Conduction velocity restitution (CVr) and vulnerability window (VW) of homogeneous tissue to reentry subject to DAD was investigated. Vulnerability of transmural ventricular strand was also quantified under normal (NF) and HF conditions

Keywords

bioelectric potentials; biological tissues; biomembrane transport; calcium; cardiovascular system; APDr; Ca²⁺; calcium handling; cellular ionic channel kinetics remodeling; conduction velocity restitution; dynamic action potential duration restitution; heart failure; human ventricular myocyte; intracellular calcium transient; rate dependent electrical activity; transmural human ventricular tissue model; vulnerability window; Astronomy; Calcium; Current density; Hafnium; Heart; Humans; Kinetic theory; Noise measurement; Physics; Strontium;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 2005

Conference_Location

Lyon

Print_ISBN

0-7803-9337-6

Type

conf

DOI

10.1109/CIC.2005.1588163

Filename

1588163