Multicompartment retinal ganglion cells response to high frequency bi-phasic pulse train stimulation: Simulation results

Author

Maturana, Matias I. ; Grayden, David B. ; Burkitt, Anthony N. ; Meffin, Hamish ; Kameneva, Tatiana

Author_Institution

Dept. of Electr. Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia

fYear

2013

fDate

3-7 July 2013

Firstpage

69

Lastpage

72

Abstract

Retinal ganglion cells (RGCs) are the sole output neurons of the retina that carry information about a visual scene to the brain. By stimulating RGCs with electrical stimulation, it is possible to elicit a sensation of light for people with macular degeneration or retinitis pigmentosa. To investigate the responses of RGCs to high frequency bi-phasic pulse train stimulation, we use previously constrained models of multi-compartment OFF RGCs. The morphologies of mouse RGCs are taken from the Chalupa set of the NeuroMorpho database. The cell models are divided into compartments representing the dendrites, soma and axon that vary between the cells. A total of 132 cells are simulated in the NEURON environment. Results show that the cell morphology plays an important role in the response characteristics of the cell to high frequency bi-phasic pulse train stimulation.

Keywords

bioelectric phenomena; cellular biophysics; vision defects; visual evoked potentials; Chalupa set; NEURON environment simulation; NeuroMorpho database; RGC response; brain; electrical stimulation; high frequency biphasic pulse train stimulation; macular degeneration; multicompartment retinal ganglion cells; output neurons; retinitis pigmentosa; visual scene; Biological system modeling; Electrical stimulation; Mathematical model; Morphology; Nerve fibers; Retina;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6609439

Filename

6609439