Ultrasonic and photoacoustic imaging of knee joints in normal and osteoarthritis rats

Author

Izumi, T. ; Sato, Mitsuhisa ; Yabe, Yuhei ; Hagiwara, Y. ; Saijo, Yoshifumi

Author_Institution

Grad. Sch. of Biomed. Eng., Tohoku Univ., Sendai, Japan

fYear

2013

fDate

3-7 July 2013

Firstpage

1116

Lastpage

1119

Abstract

Osteoarthritis (OA) is a common joint disorder and estimated to cause symptoms in 20-40% of the elderly population. 532 nm laser is much absorbed in developed vascular network in the spongy bone which is one of the main characteristics of OA. In this study, a photoacoustic (PA) imaging system with 532 nm laser and 50 MHz US (ultrasound) transducer was developed. Normal and OA knee joints were observed by US and PA imaging. PA signal from the spongy bone was strong where US reflection was very weak. PA signal from the spongy bone was significantly strong in OA compared with that in normal knee while US showed similar low intensity echo in normal and OA. Detailed structure and information on vascular density of spongy bone in rat knee joint were successfully obtained with US / PA combined imaging. US / PA imaging should be useful for early diagnosis of OA.

Keywords

biomedical equipment; biomedical optical imaging; biomedical ultrasonics; bone; diseases; medical signal detection; photoacoustic effect; ultrasonic reflection; ultrasonic transducers; US-PA combined imaging; developed vascular network; early osteoarthritis diagnosis; elderly population; frequency 50 MHz; joint disorder; laser absorption; normal knee joint; normal rat; osteoarthritis characteristics; osteoarthritis knee joint; osteoarthritis rat; photoacoustic imaging system; photoacoustic signal; spongy bone vascular density; ultrasonic imaging; ultrasound intensity echo; ultrasound reflection; ultrasound transducer; wavelength 532 nm; Bones; Educational institutions; Imaging; Joints; Osteoarthritis; Transducers; Ultrasonic imaging; Animals; Disease Models, Animal; Imaging, Three-Dimensional; Knee Joint; Male; Osteoarthritis, Knee; Photoacoustic Techniques; Rats; Rats, Sprague-Dawley; Signal Processing, Computer-Assisted; Transducers; Ultrasonics;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6609701

Filename

6609701