A mathematical model of the dynamics for anti-HBV infection treatment with Peginterferon Alfa-2a

Author

Min, Lequan ; Li, Weidong ; Su, Yongmei ; Kuang, Yang

Author_Institution

Appl. Sci. Sch., Univ. of Sci. & Technol. Beijing, Beijing

fYear

2008

fDate

25-27 May 2008

Firstpage

1295

Lastpage

1298

Abstract

Based on the anti-HBV infection therapy clinical data of the Peginterferon Alfa-2a plus placebo for HBeAg-Positive chronic hepatitis B patients, this paper establishes a mathematical model consisting of three differential equation systems and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations indicate that patients whose plasma HBV DNA levels equal the mean HBV DNA levels of all patients will need to prolong their treatment time to 19 years in order to completely eliminate the HBV virus in infected hepatocytes.

Keywords

DNA; differential equations; diseases; HBV DNA levels; HBeAg-positive chronic hepatitis B patients; Peginterferon Alfa-2a; antiHBV infection treatment; clinical data; differential equation systems; immune system; infected hepatocytes; DNA; Differential equations; Electronic mail; Immune system; Kinetic theory; Liver diseases; Mathematical model; Mathematics; Medical treatment; Statistics;

fLanguage

English

Publisher

ieee

Conference_Titel

Communications, Circuits and Systems, 2008. ICCCAS 2008. International Conference on

Conference_Location

Fujian

Print_ISBN

978-1-4244-2063-6

Electronic_ISBN

978-1-4244-2064-3

Type

conf

DOI

10.1109/ICCCAS.2008.4658004

Filename

4658004