A mathematical model of the kindling phenomenon

Author

Ferrer, Angel R.Zapata ; G, Andrés Gaona ; González, Oswaldo

Author_Institution

Lab. de Bioingenieria, Inst. Mexicano de Psiquiatria, Mexico

Volume

4

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

1573

Abstract

In this paper we present a mathematical model of the kindling phenomenon, and of the electronic system that permits the installation in the animal of an epileptic model developed by Goddard et al. [1967]. This model consists in obtaining by means of electrical stimulation in the amygdala of the cat, a paroxistic progressive activation that produces the apparition of postdischarge, which follows amplitude patterns of duration and frequency representing epileptic status. We also present an electronic system designed and built for the purpose of using it in electrical stimulation with special characteristics for the pulse width, train duration, frequency and amplitude, which will produce paroxismic discharges when stimulating a certain zone of the central nervous system (specially the amygdala)

Keywords

brain models; neural nets; neurophysiology; nonlinear dynamical systems; amplitude patterns; cat amygdala; central nervous system; electrical stimulation; electronic system; epileptic model; epileptic status; extinction; kindling phenomenon; mathematical model; neural network; paroxismic discharges; paroxistic progressive activation; postdischarge; Animals; Biological neural networks; Central nervous system; Cities and towns; Electrical stimulation; Epilepsy; Equations; Frequency; Mathematical model; Space vector pulse width modulation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.647557

Filename

647557