Water uptake behavior of tyrosine-derived carbonates and copolymers

Author

Thakur, R. ; Sousa, A. ; Libera, M. ; Michniak, B. ; Kohn, J.

Author_Institution

Dept. of Pharm. Sci., State Univ. of New Jersey, Piscataway, NJ, USA

fYear

2005

fDate

2-3 April 2005

Firstpage

197

Lastpage

199

Abstract

We measure the total water uptake and water flux in homopolymer tyrosine-derived carbonates (DTE) as well as in copolymers of DTE-PEG. We study total water uptake by ³H-labeled radioactive water, and we observe that PEG substantially increases the absorbed amount compared with the homopolymers. Likewise, flux studies reveal that flux is higher in the PEG-containing carbonates. To assess the high spatial distribution of water in these copolymers we use spatially-resolved electron energy-loss spectroscopy. For the case of DTE-8% PEG we find no statistically significant variations in water content greater than 100 nm length scales.

Keywords

biomedical materials; electron energy loss spectra; polymer blends; ³H-labeled radioactive water; copolymers; electron energy-loss spectroscopy; homopolymer; spatial distribution; tyrosine-derived carbonates; water; Biomedical measurements; Chemical technology; Compression molding; Electron microscopy; Organic materials; Pharmaceuticals; Polymer films; Spectroscopy; Throughput; Water;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2005. Proceedings of the IEEE 31st Annual Northeast

Print_ISBN

0-7803-9105-5

Electronic_ISBN

0-7803-9106-3

Type

conf

DOI

10.1109/NEBC.2005.1431990

Filename

1431990