Poly(N-isopropylacrylamide) based polymer nanogels for drug delivery applications

Author

Subhash, Dhanya ; Mody, Hardik ; Banerjee, Rinti ; Bahadur, Dhirendra ; Srivastava, Rohit

Author_Institution

Dept. of Biosci. & Bioeng., Indian Inst. of Technol. Bombay, Mumbai, India

fYear

2011

fDate

15-18 Aug. 2011

Firstpage

1741

Lastpage

1744

Abstract

Poly(N-isopropylacrylamide) (PNIPAM), a well documented and widely accepted polymer for synthesis of drug delivery nanoparticles for controlled release applications, is used in this study in conjunction with maleic acid (MA), a non-toxic, cellular component. This research aims to synthesize polymer nanogels for controlled release of drug by tuning the lower critical solution temperature (LCST) of PNIPAM to slightly above the body temperature using MA. MA was found to augment the hydrophilic nature of PNIPAM and thereby increase its LCST. MA is used in different concentrations to study its effect on the LCST of PNIPAM and polymer nanogels with size and swelling behavior ideal for biological applications have been obtained.

Keywords

biomedical materials; drug delivery systems; hydrophilicity; nanomedicine; polymer gels; PNIPAM; body temperature; controlled release; drug delivery nanoparticles; hydrophilicity; lower critical solution temperature; maleic acid; poly(N-isopropylacrylamide); polymer nanogels; Drug delivery; Drugs; Nanobioscience; Nuclear magnetic resonance; Polymers; Temperature measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanotechnology (IEEE-NANO), 2011 11th IEEE Conference on

Conference_Location

Portland, OR

ISSN

1944-9399

Print_ISBN

978-1-4577-1514-3

Electronic_ISBN

1944-9399

Type

conf

DOI

10.1109/NANO.2011.6144388

Filename

6144388