Counter flow microbubble channeling using acoustic radiation force funnel

Acoustic radiation force has become a significant factor in the research to enhance the targeting of microbubbles for molecular imaging and drug delivery. In this study microbubbles are flown through an opposing radiation force funnel and the impact on their path is compared to the theory. The experiments demonstrate that the behavior of the lipid microbubbles is in accordance with the simulation. Although the force required to stop microbubbles flowing at 10 mm/s is in the order of 100s of nN, large clusters are successfully held against the flow.