Olfactory receptors molecular sensors using surface acoustic wave chip

Author

Wu, Chunsheng ; Du, Liping ; Wang, Ping ; Zhao, Luhang

Author_Institution

Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou, China

fYear

2011

fDate

20-23 Feb. 2011

Firstpage

1196

Lastpage

1199

Abstract

We present a new surface acoustic wave (SAW) chip for odorant detection by the using of olfactory receptors as molecular sensors. The molecular sensors were originated from the expression of ODR-10 in human breast cancer MCF-7 cells, which is an olfactory receptor of C. elegances. ODR-10 was then combined with SAW chips to serve as molecular sensors for odorant detection. The resonance frequency shifts of SAW can be recorded to characterize the responses of this molecular sensor to various odorants. The recording data show this molecular sensor can recognize its natural ligand of diacetyl with high specificity and sensitivity. It is indicated that this molecular sensor has great potential to be applied in many fields such as biomedicine, environmental monitoring, and food quality control.

Keywords

chemioception; electronic noses; surface acoustic wave sensors; ODR-10; SAW chip; SAW resonance frequency shift; biomedicine; environmental monitoring; food quality control; human breast cancer MCF-7 cell; odorant detection; olfactory receptor molecular sensor; surface acoustic wave chip; Biosensors; Olfactory; Plasmas; Resonant frequency; Sensor phenomena and characterization; Surface acoustic waves; biosensors; molecular sensors; olfactory receptors; surface acoustic wave;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems (NEMS), 2011 IEEE International Conference on

Conference_Location

Kaohsiung

Print_ISBN

978-1-61284-775-7

Type

conf

DOI

10.1109/NEMS.2011.6017571

Filename

6017571