Design of logarithmic current amplifier for micro-PCR EC detection

Author

Guo, Cangran ; Yin, Ming ; Liu, Zewen ; Qing, Jian ; Zhang, Rong

Author_Institution

Inst. of Microelectron., Tsinghua Univ., Beijing, China

fYear

2011

fDate

15-17 April 2011

Firstpage

5809

Lastpage

5812

Abstract

A Logarithmic Current Mode Amplifier (LGCMA) is designed and verified by 0.5 μm process aiming at electrochemical signal detection in the miniaturized polymerase chain reaction (μPCR) chip for the quantitative analysis of deoxyribonucleic acid (DNA) concentration. Fully electronic integrated front end detection system is concepted to readout electrochemical signal using the LGCMA as a pre-amplifier. This paper has a insight to the stability, logarithmic property, bandwidth and dynamic range (DR) and noise level of the LGCMA. The post simulation result shows the operation current ranges six orders of magnitude from 5 pA to 5 μA. Considering that noise presented in the circuits the minimum current resolution is InA.

Keywords

CMOS analogue integrated circuits; DNA; bioMEMS; current-mode circuits; electrochemical analysis; preamplifiers; signal detection; μPCR chip; CMOS process; DNA concentration; DR; LGCMA; current 1 nA; current 5 pA to 5 muA; deoxyribonucleic acid concentration; dynamic range; electrochemical signal detection; fully electronic integrated front end detection system; logarithmic current mode amplifier; logarithmic property; microPCR EC signal detection; miniaturized polymerase chain reaction chip; minimum current resolution; operation current; preamplifier; quantitative analysis; size 0.5 mum; Current measurement; DNA; Electrodes; Integrated circuit modeling; Noise; Noise level; Simulation; µPCR; electrochemical detection; logarithmic current mode amplifier(LGCMA); minimum current resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Electric Information and Control Engineering (ICEICE), 2011 International Conference on

Conference_Location

Wuhan

Print_ISBN

978-1-4244-8036-4

Type

conf

DOI

10.1109/ICEICE.2011.5778308

Filename

5778308