Cell-mediated mineralization model for bioprosthetic heart valve tissue

Author

Ng, Grace ; Hwang, Ned H C ; Cheung, Herman S.

Author_Institution

Dept. of Biomed. Eng., Miami Univ., Coral Gables, FL, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Calcification is the major cause of degeneration in bioprosthetic heart valves. One possible solution to the problem is to coat the surface of the heart valve with anti-mineralization agents, which are known to inhibit soft tissue calcification, e.g. phosphocitrate and bisphosphonates. However, there are a few steps that must be performed before coating the surface of the heart valve with these agents. The focus of this paper is on these intermediate steps, which led to the design of a cell-mediated mineralization model for bioprosthetic heart valve tissue

Keywords

biochemistry; biological tissues; cardiology; cellular biophysics; prosthetics; bioprosthetic heart valve tissue; bioprosthetic heart valves degeneration; bisphosphonates; cell-mediated mineralization model; heart valve surface coating; phosphocitrate; soft tissue calcification inhibition; Biological tissues; Biomedical engineering; Calcium; Coatings; Crystals; Heart valves; Humans; In vitro; In vivo; Mineralization;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803916

Filename

803916