Modeling electrodiffusion in the outer hair cell

Author

Halter, J.A. ; Nygren, A. ; Brownell, W.E.

Author_Institution

Baylor Coll. of Med., Houston, TX, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Presents a distributed-parameter electrodiffusion model of the outer hair cell which allows for prediction of the spatio-temporal character of the ion concentration dynamics due to radial and longitudinal ion flux in the working volumes: the extra-cisternal space, axial core and lumped stereocilia. The Nernst-Planck relation is used to represent longitudinal electrodiffusion as a function of the spatial distribution of ion concentration and electric potential. The model allows for definition of the spatial distribution and kinetics of an arbitrary set of ion channels in the plasma membrane and subsurface cisternae. The spatio-temporal properties of the predicted component potentials and concentrations are presented for both the in-vitro case, considering basal current injection, and the in-vivo case, considering modulation of the silent current by the mechano-electric transduction channels

Keywords

biodiffusion; bioelectric potentials; biomembrane transport; ear; mechanoception; physiological models; Nernst-Planck relation; axial core; basal current injection; distributed-parameter electrodiffusion model; electric potential; extra-cisternal space; in-vitro case; in-vivo case; ion channels; ion concentration dynamics; kinetics; longitudinal electrodiffusion; longitudinal ion flux; lumped stereocilia; mechano-electric transduction channels; modulation; outer hair cell; plasma membrane; predicted component potentials; radial ion flux; silent current; spatial distribution; spatio-temporal character; spatio-temporal properties; subsurface cisternae; working volumes; Biomembranes; Educational institutions; Electric potential; Hair; In vitro; Kinetic theory; Mechanical factors; Nonlinear equations; Plasma properties; Predictive models;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.804342

Filename

804342