A computer model of ocular hydrodynamics

Author

Kiel, J.W.

Author_Institution

Health Sci. Center, Texas Univ., San Antonio, TX, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Describes a mathematical model of the fluid movements in eye responsible for the generation of the intraocular pressure (IOP). The model was written in STELLA (high performance systems), and includes: ciliary and choroidal hemodynamics, the Starling equilibria for ciliary capillary ultrafiltration and passive fluid flux across the non-pigment epithelium (NPE), active secretion via generation of an osmotic gradient across the NPE, aqueous outflow via trabecular and uveoscleral pathways, and the IOP. Model simulations were verified experimentally or are consistent with in vitro studies and current concepts of aqueous dynamics. The model is useful for teaching ocular hydrodynamics and generating experimental hypotheses

Keywords

biological fluid dynamics; biology computing; digital simulation; eye; haemodynamics; physiological models; STELLA; Starling equilibria; active secretion; aqueous dynamic; aqueous outflow; choroidal hemodynamics; ciliary capillary ultrafiltration; ciliary hemodynamics; computer model; eye; fluid movements; high performance systems; intraocular pressure; mathematical model; model simulations; nonpigment epithelium; ocular hydrodynamics; osmotic gradient; passive fluid flux; trabecular pathways; uveoscleral pathways; Blood flow; Circuit simulation; Education; Fluid dynamics; Fluids and secretions; Hemodynamics; Hydrodynamics; In vitro; Mathematical model; Physiology;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.804486

Filename

804486