Fabrication of a tissue-equivalent cardiovascular valve

Author

Neidert, M.R. ; Tower, T.T. ; Oegema, T.R. ; Tranquillo, R.T.

Author_Institution

Dept. of Chem. Eng., Minnesota Univ., Minneapolis, MN, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Describes a mold to fabricate multileaflet “valve-equivalents” based on the tissue-equivalent approach of entrapping tissue cells in a self-assembled biopolymer scaffold which the cells compact. The mold design results in leaflet structures possessing circumferential alignment characteristic of native leaflets. The authors report on the geometry, alignment, and mechanical properties for the valve-equivalent leaflets

Keywords

biological tissues; biomechanics; cardiology; cellular biophysics; mechanical properties; prosthetics; bioprosthesis; bovine dermal collagen; circumferential alignment; leaflet structures; mold design; native leaflets; self-assembled biopolymer scaffold; tissue cells entrapping; tissue-equivalent cardiovascular valve fabrication; valve-equivalent leaflets; Cardiac disease; Cardiology; Cardiovascular diseases; Compaction; Fabrication; Plugs; Poles and towers; Roentgenium; Valves;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.804503

Filename

804503