DocumentCode
3330082
Title
Notice of Retraction
Application of Response Surface Methodology for the Optimization of Partition Conditions of Emodin in Aqueous Two-Phase System
Author
Yuan-Qing Ling ; Hua-Li Nie ; Wei Nie ; Li-Min Zhu ; Branford-White, Christopher J.
Author_Institution
Coll. of Chem., Chem. Eng. & Biotechnol., Donghua Univ., Shanghai, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
4
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The purification of emodin in an aqueous two-phase system (ATPS) composed of tert-Butanal and sodium chloride was optimized by using response surface methodology (RSM). A central composite design was used to evaluate the influence of initial emodin concentration, pH, and concentration of tert-Butanol and sodium chloride on the extraction yield of emodin. The optimum conditions were determined as emodin 6.49μg/ml, pH 4.27, tert-Butanol 0.25% (v/v) and sodium chloride 011g/ml. It was observed that sodium chloride increased emodin partitioning. The optimal condition gave a yield of 92.04% for emodin partitioning and it was a good result for a first step purification.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The purification of emodin in an aqueous two-phase system (ATPS) composed of tert-Butanal and sodium chloride was optimized by using response surface methodology (RSM). A central composite design was used to evaluate the influence of initial emodin concentration, pH, and concentration of tert-Butanol and sodium chloride on the extraction yield of emodin. The optimum conditions were determined as emodin 6.49μg/ml, pH 4.27, tert-Butanol 0.25% (v/v) and sodium chloride 011g/ml. It was observed that sodium chloride increased emodin partitioning. The optimal condition gave a yield of 92.04% for emodin partitioning and it was a good result for a first step purification.
Keywords
biochemistry; organic compounds; pH; purification; response surface methodology; sodium compounds; NaCl; aqueous two-phase system; central composite design; emodin purification; extraction yield; pH; partition condition optimization; response surface methodology; sodium chloride; tert-Butanol; Analysis of variance; Compounds; Mathematical model; Optimization; Purification; Regression analysis; Response surface methodology;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5780691
Filename
5780691
Link To Document