Computer model of myocardial electronic interactions and its applications

A discrete model was developed which reproduces the intercellular electrophysiological processes within a block of myocardial tissue. The behavior of individual elements is introduced in the form of the digitized physiologic and premature action potentials which are comprehended as series of jumps between discrete polarization levels. For each cellular element, the model introduces the excitation threshold as the minimum electric flow in the surrounding which can excite the cell, and the sensitivity towards the electronic interactions which can advance or slow down the depolarization and repolarization processes of the cell. The excitation threshold and the electronic sensitivity are dependent on the current polarity of the element. The numerical solution of the model is based on discrete planning of asynchronous events. The time increments are dynamically computed according to the chosen precision of the discrete polarity levels. The model enables efficient simulation of the electrophysiological properties in three-dimensional models of the myocardial tissue. A detailed formal description of the model is given and two series of experiments are presented