Cell-Based Microfluidic Biochip for Electrochemical Real-Time Monitoring of Glucose and Oxygen

Author

Rodrigues, N. Pereira ; Kimura, H. ; Sakai, Y. ; Fujii, T.

Author_Institution

Univ. of Tokyo, Tokyo

fYear

2007

fDate

10-14 June 2007

Firstpage

843

Lastpage

846

Abstract

In this study, we developed a new cell-based biochip dedicated to the real-time and on-line monitoring of transient effluxes of glucose and oxygen. This microfluidic device "on a chip" will therefore be dedicated and realize a complete, precise and real-time monitoring of the composition and modulation of cell medium. The microdevice is composed of arrays of amperometric microsensors integrated in the inlet and the outlet of a PDMS cell chamber. First results dedicated to glucose and oxygen calibration in the dynamic conditions of liquid flow showed good performances of the integrated microsensors in terms of linearity of response and sensitivity of detection in a physiological buffer medium.

Keywords

amperometric sensors; electrochemical analysis; microfluidics; microsensors; monitoring; PDMS cell chamber; amperometric microsensors; electrochemical real-time monitoring; glucose; microfluidic biochip; oxygen; physiological buffer; Biomedical measurements; Biomedical monitoring; Biosensors; Chemical and biological sensors; Electrodes; Fluid flow; Microfluidics; Microsensors; Oxygen; Sugar; PDMS microfluidic biochip; glucose; integrated amperometric microsensors; oxygen;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300262

Filename

4300262