Increasing the tensile strength of skin wound at early healing period

Six groups of rats consisting of twelve each were used to evaluate the tensile strength of the skin wound at an early healing period. Effects of Zyplast implant and platelet-derived growth factor on the tensile strength of wounds created on the backs of rats were studied. The results indicate that, the addition of Zyplast to the wounds resulted in significantly lower tensile strength in wounds closed with or without tension as compared to controls. The addition of platelet-derived growth factor to Zyplast treated wounds resulted in significantly higher tensile strength overall as compared to Zyplast treated groups alone. The negative effect of Zyplast on wounds closed with or without tension were overcome by widespread positive effects of platelet-derived growth factor on wound healing.