Construction details of an autoradiographic-based rat brain phantom for emission tomography

Author

Dougherty, D.A. ; Nissanov, J. ; Gindi, G.R.

Author_Institution

Dept. of Anatomy, State Univ. of New York, Stony Brook, NY, USA

Volume

2

fYear

1998

fDate

1998

Firstpage

1250

Abstract

A digital brain phantom was created from rat brain autoradiographic (AR) data for use in emission computed tomography studies. The animal tissue was radio-labeled with [¹⁴C]-2-deoxyglucose, a functional analog of the PET agent [ ¹⁸F]-fluro-deoxyglucose. Following sacrifice of the animal, serial tissue sections were cut at 20 μm thickness, digitized, and calibrated to represent the ground truth 2D relative spatial distribution of radionuclide within the tissue. A 3D representation was achieved by digital alignment of the serial AR images to corresponding video blockface images acquired at the time of cutting. In addition, a magnetic resonance data set was co-registered to the AR and blockface data using the AIR algorithm. This paper is concerned with outlining the details of construction for this phantom

Keywords

biomedical MRI; brain; emission tomography; positron emission tomography; 20 mum; PET agent; [¹⁴C]-2-deoxyglucose; [¹⁸F]-fluro-deoxyglucose; animal tissue; digital brain phantom; emission computed tomography; ground truth 2D relative spatial distribution; magnetic resonance data set; radionuclide; rat brain autoradiographic data; serial tissue sections; video blockface images; Animals; Image quality; Image reconstruction; Image segmentation; Imaging phantoms; Medical tests; Nuclear medicine; Positron emission tomography; Skull; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium, 1998. Conference Record. 1998 IEEE

Conference_Location

Toronto, Ont.

ISSN

1082-3654

Print_ISBN

0-7803-5021-9

Type

conf

DOI

10.1109/NSSMIC.1998.774384

Filename

774384