Development of a finite element model of molecular diffusion in living brain from in vivo magnetic resonance

Author

McQueen, P.G. ; Jin, A.J. ; Pierpaoli, C. ; Basser, P.J.

Author_Institution

Nat. Inst. of Health, Bethesda, MD, USA

fYear

1996

fDate

29-31 Mar 1996

Firstpage

289

Lastpage

292

Abstract

Magnetic resonance imaging techniques measure in vivo the diffusion tensor of water in tissues. With some physiologically reasonable assumptions, this data can be incorporated into a finite element model of diffusive transport of macromolecules within living tissue. Here the authors present the results of applying this approach to model the transport of sucrose in living cat brain. They show that white matter fibers strongly bias the transport due to their anisotropic diffusive properties

Keywords

biodiffusion; biological NMR; brain models; finite element analysis; molecular biophysics; water; H₂O; anisotropic diffusive properties; finite element model; in vivo magnetic resonance; living cat brain; macromolecules transport; molecular diffusion; physiologically reasonable assumptions; sucrose; water diffusion tensor; white matter fibers; Anisotropic magnetoresistance; Brain modeling; Coils; Diffusion tensor imaging; Finite element methods; Image resolution; In vivo; Magnetic resonance imaging; Sugar; Tensile stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern

Conference_Location

Dayton, OH

Print_ISBN

0-7803-3131-1

Type

conf

DOI

10.1109/SBEC.1996.493206

Filename

493206