Effects of Ginsenoside Re on myocardial ischemia reperfusion injury

To investigate the role of Ginsenoside Re on myocardial ischemia reperfusion injury in rats model and its possible protective mechanism. 40 rats were randomly divided into 4 groups: sham operated group, ischemia reperfusion group and Ginsenoside Re treatment groups. Several important hemodynamic parameters were determined. Levels of MDA cTnI, CK-MB and activities of SOD, CAT and GSH-Px in serum were determined; The myocardial ultrastructure was observed under electron microscope; Reperfusion arrhythmia were recorded. As compared with myocardial ischemia reperfusion injury group, animals treated with Ginsenoside Re showed improved hemodynamics, a decreasing rate of reperfusion arrhythmia, a declined levels of MDA, cTnI and CK-MB in serum. The activities of SOD, CAT and GSH-Px in animals treated with Ginsenoside Re increased and the ultrastructure of myocardial in Ginsenoside Re group was kept much more stable than that in ischemia-reperfusion group. Ginsenoside Re have a protective effect on myocardial ischemia reperfusion injury in rat model, and its mechanism may be related to the alleviation of damages caused by oxygen free radical.