MRI observation and pathological correlation study of rat C6 brain glioma

SD rat C6 brain glioma model is established, and observe its pathological characteristic and MRI. C6 glioma cells were implanted through stereotactic orientator, and C6 brain glioma rat model was established. The change of tumor body growth (MRI) at Week 1, 2 and 3 after the implantation was observed, and compared with gross pathological results. The intracranial implantation via stereotactic orientation had a success rate of 100%, and there was no distal and extracranial metastasis. As shown by T2WI and enhanced T1WI scanning, tumor body grew with peritumor edema at the end of Week 1 after the implantation, and grew rapidly to a volume approximate to gross pathological results two weeks later. It had a high success rate to establish rat C6 brain glioma model through stereotactic orientation. MRI + pathological examination could better reflect the growth way and development process of tumor.