The role of SBHL in tumor growth and immune functions in mice

Author

Ai Jin-Xia

Author_Institution

Dept. of Immunology, Beihua Univ., Jilin, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

521

Lastpage

523

Abstract

To investigate the effects of solasodine hydrochloride (SBHL) on tumor growth and its anti-tumor immune response mechanisms. Methods: S180, tumor-bearing mice were treated by intraperitoneal injection of SBHL [10, 30, 50 mg / (kg.d)], after a continuous injection of 14 days, tumor growth and the effects of SBHL on immune functions were observed. Results : SBHL significantly inhibited the growth of S180 sarcoma, positively regulated the inhibited immune function of S180, also promoted the lymphocyte proliferation and increased IL-2 production capacity and enhanced NK and LAK cell activity. Conclusion : These results suggested that SBHL can inhibit tumor growth; the immune enhancement effects of SBHL may exert its anti-tumor effects of an important way.

Keywords

biomedical materials; blood; cancer; cellular biophysics; organic compounds; tumours; IL-2 production capacity; LAK cell activity; NK cell activity; S180 sarcoma; SBHL; antitumor immune response mechanism; immune function; intraperitoneal injection; lymphocyte proliferation; solasodine hydrochloride; tumor growth; tumor-bearing mice; Cells (biology); Educational institutions; Immune system; Mice; Suspensions; Tumors; IL-2; LAK activity; NK activity; Tumor-bearing mice; solasodine hydrochloride;

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6028362

Filename

6028362