Effects of Geraniin in Geranium sibiricum L. on antioxidant function of S180 mice

Author

Jin Zhexiong ; Sun Renshuang

Author_Institution

Coll. of Pharmacy, Harbin Univ. of Commerce, Harbin, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

896

Lastpage

899

Abstract

Objective: to investigate effects of Geraniin in Geranium sibiricum L. on antioxidant function of S₁₈₀ mice. Methods: S₁₈₀ entity-tumor mice as study model were used to investigate effects of Geraniin on tumor inhibition rate and indices of immune organs of S₁₈₀ mice; kits were used to determine SOD activity and T-AOC activity in red blood cells and MDA content of red blood cells in the whole blood of S₁₈₀ mice. Results: Geraniin could significantly inhibit growth of S₁₈₀ entity-tumor, significantly increase thymus index and spleen index, significantly increase SOD activity and T-AOC activity in red blood cells of S₁₈₀ mice and significantly reduce MDA content of red blood cells in the whole blood of S₁₈₀ mice. Conclusion: Geraniin could significantly inhibit the growth of entity-tumors of S₁₈₀ mice and its effect mechanism was possibly associated with increase of antioxidant function of S₁₈₀ entity-tumor mice.

Keywords

biochemistry; blood; cellular biophysics; drugs; enzymes; molecular biophysics; tumours; Geraniin; Geranium sibiricum L; RBC MDA content; S₁₈₀ entity tumor mice; SOD activity; T-AOC activity; antioxidant function; geraniin effects; immune organ indices; red blood cells; spleen index; superoxide dismutase; thymus index; total antioxidant capacity; tumor inhibition rate; Cancer; Educational institutions; Electron tubes; Mice; Red blood cells; Tumors; Anti-oxidant function; Geraniin; Geranium sibiricum L; S180 mice;

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6028967

Filename

6028967