Effect of sequencing on the interaction of hyperthermia and photodynamic therapy

Author

Carter, Sherry J. ; Judy, Millard M. ; Howard, Lorn L.

Author_Institution

Southern Methodist Univ., Dallas, TX, USA

fYear

1988

fDate

4-7 Nov. 1988

Firstpage

1126

Abstract

The effect of the order of application of hyperthermia and photodynamic therapy on the effectiveness of the combination therapy was investigated. The experiments were performed at 41 degrees C and 42 degrees C with Chinese hamster ovary cells. For heat application prior to DHE sensitization, the interaction of the two therapies is less than additive for a 41 degrees C heat exposure, and greater than additive for a 42 degrees C heat exposure. For heat applications during irradiation, the interaction of the two therapies is additive for both levels of heat exposure. For heat application following irradiation, the interaction of the two therapies is slightly greater than additive for a 41 degrees C heat exposure and greater than additive for a 42 degrees C heat exposure. Two conclusions are drawn: (1) sequencing is an important factor in the interaction of these two therapies; and (2) the most effective order of application is dependent on the temperature.<>

Keywords

biothermics; cellular effects of radiation; radiation therapy; 41 degC; 42 degC; 630 nm; Chinese hamster ovary cells; DHE sensitization; combination therapy; effective application order; heat application; heat exposure; hyperthermia; irradiation; light exposure; photodynamic therapy; sequencing effect;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE

Conference_Location

New Orleans, LA, USA

Print_ISBN

0-7803-0785-2

Type

conf

DOI

10.1109/IEMBS.1988.94774

Filename

94774