A multifunctional cell-based impedance biosensor system for cardiovascular drug and marine toxin analysis

With regard to electrical cell-substrate impedance sensor (CIB), the cardiomyocyte beating detection turns out to be a novel application. In this study, a multifunctional cell-based impedance biosensor system is established using cell-based impedance biosensor as the sensitive element. Cellular growth and beating experiments are carried out to verify the multifunction of the biosensor system. One typical marine diarrhetic toxin okadaic acid (OA) is used for cytotoxicity analysis and one heart-related compound isradipine is employed for cardiotoxicity analysis. Based on the multifunction, the multifunctional cell-based impedance biosensor system will become a utility approach for cardiovascular drug and marine toxin analysis.