• DocumentCode
    3462019
  • Title

    Precise control of DNA orientation for improved functionlity in protein binding microarrays

  • Author

    Spuhler, P. ; Xirui Zhang ; Monroe, Megan ; Greenspun, J. ; Unlu, M.S. ; Sola, L. ; Chiari, M.

  • Author_Institution
    Biomed. Eng., Boston Univ., Boston, MA, USA
  • fYear
    2011
  • fDate
    8-11 Aug. 2011
  • Firstpage
    91
  • Lastpage
    92
  • Abstract
    We demonstrate controlled orientation of surface anchored DNA and utilize spectral self-interference fluorescent microscopy (SSFM) to measure fluorophore height with sub-nm precision to precisely quantify DNA orientation and conformation.
  • Keywords
    DNA; fluorescence; molecular biophysics; molecular configurations; proteins; DNA orientation; fluorophore height; protein binding microarrays; spectral self-interference fluorescent microscopy; surface anchored DNA; DNA; Fluorescence; Polymers; Probes; Protein engineering; Proteins; DNA biosensor; bioNEMS; protein binding microarrays;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Optical MEMS and Nanophotonics (OMN), 2011 International Conference on
  • Conference_Location
    Istanbul
  • ISSN
    2160-5033
  • Print_ISBN
    978-1-4577-0334-8
  • Type

    conf

  • DOI
    10.1109/OMEMS.2011.6031084
  • Filename
    6031084
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3462019