Hypertension of cardiac origin: a model study

Author

Hsieh, J.-C. ; Chen, Shih-Ann ; Tai, Cheng-Jeng ; Li, John K -J

Author_Institution

Dept. of Biomed. Eng., Yuan-Pei Inst. of Med. Technol., Taiwan

Volume

1

fYear

1999

fDate

1999

Abstract

A modified Windkessel model was used to investigate interactions between peripheral resistance and ejection fraction in determining hypertension. Experimental aortic pressure, Pa(t), and aortic flow, Qa(t), data from mongrel dogs with an average of 23 kg were digitized and then incorporated into a three-element lumped arterial system model. By manipulating peripheral resistance (Rs), systemic capacitance (Cs), and Qa(t), the Pa(t) was studied. Results indicated that elevated Pa(t) caused by increased ejection fraction (EF) can be observed within normal or reduced peripheral impedance. Thus anti-hypertensive drugs using vasodilator could not be effective if cardiac origin of hypertension is involved

Keywords

cardiovascular system; diseases; haemodynamics; physiological models; anti-hypertensive drugs; aortic flow; aortic pressure; cardiac origin; ejection fraction; hypertension; model study; modified Windkessel model; mongrel dogs; peripheral resistance; systemic capacitance; three-element lumped arterial system model; vasodilator; Biomedical engineering; Capacitance; Dogs; Electrical resistance measurement; Equations; Hemodynamics; Hypertension; Immune system; Predictive models; Pressure measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802303

Filename

802303