Factor analysis for the quantification of renal cortical blood flow using O-15 water dynamic PET

Author

Ahn, J.Y. ; Seo, K. ; Lee, J.S. ; Lee, D.S.

Author_Institution

Dept. of Nucl. Med., Seoul Nat. Univ., South Korea

Volume

3

fYear

2000

fDate

2000

Abstract

The renal cortical blood flow is an important index for the estimation of kidney function. Positron emission tomography (PET) allows noninvasive and quantitative estimate of blood flow. We applied factor analysis to O-15 water dynamic renal PET images to extract pure arterial and renal cortical time activity curves (TACs) for the estimation of renal cortical blood flow. Microsphere experiment was also performed to validate the renal cortical blood flow by factor analysis. In all the cases, factor images and their TACs could be extracted successfully. Input function by factor analysis and by arterial blood sampling was nearly same, except for the delay and dispersion. The renal cortical blood flow by factor analysis was within normal range (1.23-2.46 ml/min/g). In microsphere study, the flow by factor analysis was 2.49±0.47 ml/min/g and by microsphere was 2.52±0.19 ml/min/g

Keywords

blood flow measurement; kidney; medical image processing; positron emission tomography; principal component analysis; ¹⁵O water dynamic renal PET images; PCA; arterial blood sampling; cortical time activity curves; dynamic positron emission tomography; factor analysis; kidney function; microsphere study; noninvasive quantification; renal cortical blood flow; Arteries; Biomedical imaging; Blood flow; Dogs; Image analysis; Image sampling; Myocardium; Nuclear medicine; Positron emission tomography; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2000 IEEE

Conference_Location

Lyon

ISSN

1082-3654

Print_ISBN

0-7803-6503-8

Type

conf

DOI

10.1109/NSSMIC.2000.949260

Filename

949260