Photocrosslinkable poly(ethylene oxide) and poly(vinyl alcohol) hydrogels for tissue engineering cartilage

Author

Bryant, Stephanie J. ; Anseth, Kristi S.

Author_Institution

Dept. of Chem. Eng., Colorado Univ., Boulder, CO, USA

Volume

2

fYear

1999

fDate

36434

Abstract

Photopolymerizable hydrogels are attractive for tissue-engineered applications because of their high water content, tissue-like mechanical properties, and ability to be polymerized in vivo under physiological conditions. We are interested in using photocrosslinkable macromers of poly(ethylene oxide) (PEG) and poly(vinyl alcohol) (PVA) to encapsulate chondrocytes for cartilage tissue regeneration. Our aim is to optimize the network composition and structure to facilitate regeneration of type-specific cartilage in a hydrogel that will temporarily withstand the normal loads of natural cartilage. We have demonstrated that cartilage produced in two hydrogel systems resulted in 6.7±1.2% (PVA) and 1.5±0.8% (PEG) total glycosaminoglycans and 2.5±2% (PVA) and 6.5±0.7% (PEG) total collagen per wet weight of cartilage after 6 and 7 weeks, respectively

Keywords

biological tissues; biomedical materials; gels; photochemistry; polymer solutions; polymerisation; swelling; cartilage tissue regeneration; chondrocytes encapsulation; compressive modulus; equilibrium swelling; high water content; network composition; photocrosslinkable; photopolymerizable hydrogels; poly(ethylene oxide) hydrogels; poly(vinyl alcohol) hydrogels; tissue engineering cartilage; tissue-like mechanical properties; type-specific cartilage; Chemical engineering; Chemistry; Encapsulation; In vivo; Mechanical factors; Organic light emitting diodes; Polymers; Regeneration engineering; Tissue engineering; Water;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803906

Filename

803906