First in vivo studies on rats with the YAPPET scanner

Author

Guerra, A. Del ; Damiani, C. ; Domenico, G. Di ; Giganti, M. ; Motta, A. ; Piffanelli, A. ; Uccelli, L. ; Zavattini, G. ; Bettinardi, V. ; Gilardi, M.C. ; Moresco, R.M. ; Fazio, F.

Author_Institution

Dept. of Phys., Pisa Univ., Italy

Volume

3

fYear

1999

fDate

1999

Firstpage

1475

Abstract

At Ferrara University the authors have built a dedicated 3-D PET scanner (YAPPET) with a very high spatial resolution and sensitivity as necessary for radiopharmaceutical studies on rats and mice. In collaboration with the Institute H.S. Raffaele in Milano the authors have performed both distribution and dynamical uptake studies of various radioactive tracers in rats. They have performed tomographic studies after injecting live rats with FDG and FESP labeled with ¹⁸F, with FE-CIT and Flumazenil labeled with ¹¹C, and with ¹⁸F. The ¹⁸F-FDG, ¹⁸F-FESP and ¹¹C-FE-CIT images show the different distribution of the various tracers in the rat brain. The ¹⁸F was injected for imaging the rat skeleton. In addition, the authors studied the uptake and washout curve of ¹¹C Flumazenil in the rat brain from tomographic images

Keywords

biomedical equipment; brain; image resolution; orthopaedics; positron emission tomography; ¹¹C; ¹¹C-FE-CIT; ¹⁸F; ¹⁸F-FDG; ¹⁸F-FESP; C; F; FE-CIT; FESP; Ferrara University; Flumazenil; Institute H.S. Raffaele; YAPPET scanner; dedicated 3-D PET scanner; dynamical uptake studies; in vivo studies; mice; radiopharmaceutical studies; rat skeleton; rats; spatial resolution; tomographic studies; Animals; Detectors; Image reconstruction; Imaging phantoms; In vivo; Mice; Physics; Positron emission tomography; Rats; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium, 1999. Conference Record. 1999 IEEE

Conference_Location

Seattle, WA

ISSN

1082-3654

Print_ISBN

0-7803-5696-9

Type

conf

DOI

10.1109/NSSMIC.1999.842837

Filename

842837