Utilizing MRI information to estimate F18-FDG distributions in rat flank tumors

Author

Bowsher, James E. ; Yuan, Hong ; Hedlund, Laurence W. ; Turkington, Timothy G. ; Akabani, Gamal ; Badea, Alexandra ; Kurylo, William C. ; Wheeler, C. Ted ; Cofer, Gary P. ; Dewhirst, Mark W. ; Johnson, G. Allan

Author_Institution

Dept. of Radiol., Duke Univ. Med. Center, Durham, NC, USA

Volume

4

fYear

2004

fDate

16-22 Oct. 2004

Firstpage

2488

Abstract

This paper investigates the potential of magnetic resonance imaging (MRI) to improve the estimation of within-tumor variations in F18-FDG concentration. An image model is described for incorporating MRI images into positron emission tomography (PET) and single photon emission computed tomography (SPECT) radiotracer image reconstruction. The model promotes greater smoothing, of estimated radiotracer concentration, among nearby voxels that have more nearly similar MRI signals. R3230 mammary adenocarcinomas are grown on rat flanks. Autoradiography, histology, and T2-weighted MRI are used to demonstrate that the above image model accurately reflects true F18-FDG distributions in R3230 tumors. In vivo F18-FDG distributions are then reconstructed from PET projection data, with and without incorporating MRI. The F18-FDG images reconstructed with MRI show greater detail, and this additional detail is consistent with the results of the autoradiography and histology studies.

Keywords

biological tissues; biomedical MRI; image reconstruction; radioactive tracers; radioisotope imaging; single photon emission computed tomography; tumours; F18-FDG distributions; PET; R3230 mammary adenocarcinomas; SPECT radiotracer image reconstruction; T2-weighted MRI; autoradiography; histology; image model; magnetic resonance imaging; positron emission tomography; radiotracer concentration; rat flank tumors; single photon emission computed tomography; Cancer; Computed tomography; High-resolution imaging; Image reconstruction; Magnetic resonance imaging; Neoplasms; Positron emission tomography; Single photon emission computed tomography; Smoothing methods; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2004 IEEE

ISSN

1082-3654

Print_ISBN

0-7803-8700-7

Type

conf

DOI

10.1109/NSSMIC.2004.1462760

Filename

1462760