A new CMOS/microfluidic interface for cells manipulation and separation in LoC devices

We propose in this paper a new fully integrated CMOS interface dedicated for cells manipulation and separation in LoC devices. The proposed interface includes all microelectronics circuits for dielectrophoretic manipulation and capacitive detection. It contains also an embedded frequency and phase micro controller to ensure several kinds of cells displacements such as rotation, translation and separation with a wide tunable frequency band of 250 kHz for LoC applications. Furthermore, the detection part is a charge-based capacitive measurement circuit with a high sensitivity of 10 mV for each 1 fF. This new chip is a fully integrated CMOS interface into a LoC device including both the microfluidic and the microelectronics structures. It represents one of the first microfluidic processors.