Weighted MRI-Based bowsher priors for SPECT brain image reconstruction

This paper presents a generalization of the Bowsher prior for SPECT reconstruction using anatomical prior. Instead of considering a binary selection of the neighbors of each reconstructed voxel based on the anatomical prior values, each neighbors are taken into account with a suitable weight. We tried three different weights. We showed that, for brain SPECT reconstruction using MRI, in the case of perfect registration, the weighted Bowsher prior give similar results to the regular Bowsher prior. In the case of misregistration, the weighted Bowsher prior outperforms the Bowsher prior.