• DocumentCode
    3543420
  • Title

    Effect of flow on prostaglandin E2 production and inositol trisphosphate levels in cultured osteoblasts

  • Author

    Reich, Kathleen ; Gay, Carol ; Frangos, John

  • Author_Institution
    Dept. of Chem. Eng., Pennsylvania State Univ., University Park, PA, USA
  • fYear
    1990
  • fDate
    26-27 Mar 1990
  • Firstpage
    152
  • Lastpage
    153
  • Abstract
    In order to determine what effects flow has on prostaglandin production, prostaglandin E2 levels were analyzed in perfusing media. To examine the effect of flow on cultured osteoblasts, intracellular concentrations of inositol trisphosphate were measured. It is shown that prostaglandin E2 production is increased in cells exposed to either steady or pulsatile flow. Flow-caused oscillations were observed in the intracellular levels of inositol trisphosphate. These responses are both shear and time dependent
  • Keywords
    biorheology; bone; cellular biophysics; cultured osteoblasts; flow caused oscillations; inositol trisphosphate; intracellular concentrations; monolayered cultures; perfusing media; prostaglandin E2 levels; prostaglandin E2 production; pulsatile flow; shear dependent; time dependent; Biochemistry; Bones; Cells (biology); DNA; Humans; Joints; Production; Stress;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioengineering Conference, 1990., Proceedings of the 1990 Sixteenth Annual Northeast
  • Conference_Location
    State College, PA
  • Type

    conf

  • DOI
    10.1109/NEBC.1990.66329
  • Filename
    66329
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3543420