Diagnosis abnormal cervical tissue by elastic light scattering spectroscopy and correlation with the results of Pap-smear examination

We have investigated the potential application of elastic light single-scattering spectroscopy in detection of cervical precancerous lesions non-invasively and in real time. Ex-vivo spectroscopic measurements were performed on 95 cervix biopsy tissue of 60 patients. Normal cervix tissue from 10 patients after hysterectomy was used as a control group. It was found that the spectral slope was positive and negative for the spectra taken on normal cervix and precancerous cervix tissue respectively. Sign of the spectral slopes were used as a parameter to differentiate normal cervix tissue from dysplastic cervix tissue. Elastic light single-scattering spectroscopy measurements in defining cervical tissue were 100% consistent with Pap-smear results.