Nonlinear model predictive control of a lipase production bioprocess

This paper deals with the design of a nonlinear model predictive control (NMPC) scheme for the regulation of the substrate concentration in a lipase production bioprocess that takes place inside a Fed-batch Bioreactor. The NMPC control structure is based on the nonlinear model of the process whose parameters are known and all the states are measurable. Minimization of the cost function is realized using the Levenberg-Marquardt numerical optimization method. Some simulation results are given to illustrate the efficiency of the proposed control strategy.