A scalable high-density electrochemical biosensor array for parallelized point-of-care diagnostics

This paper describes the design and verification of a prototype high-density electrochemical biosensor array for miniaturizing and enabling portable diagnostics devices that require high parallelizability. The prototype consists of a low-leakage 16-channel bi-potentiostat capable of running an electrochemical technique known as coulostatic discharge that is scalable for use with high-density sensors. Custom electronics with leakage of less than 100 fA were designed to interface with custom 4×4 nano-feature sensor array chips. By using a reversible redox molecule pair, we verified both preliminary simulated and measurement results of our system to varying redox concentrations.