Non-enzymatic graphene-based biosensors for continous glucose monitoring

A novel mediator-free, non-enzymatic electrochemical sensor, based on a graphene-Schottky junction, was fabricated for glucose detection. The sensor offers a promising alternative to the conventional enzyme-catalyzed electrochemical continuous glucose monitoring systems (CGM), as it overcomes many of the drawbacks attributed to the enzymatic nature; namely, irreversibility, drift, and interference with body fluids, which affect their accuracy, reliability and longevity. Enhanced performance of the sensors is demonstrated through the band interaction at the graphene-Schottky junction, which yields stronger forward/reverse currents in response to 50 μL glucose drop. Under optimized conditions, the linear response of the sensor to glucose concentration was valid in the range from 0 to 15 mmol/L with a detection limit of 0.5 mmol/L The results indicated that the proposed sensor provided a highly sensitive, more facile method with good reproducibility for continuous glucose detection.