Modelling pharmacological block of rapid delayed rectifier current by E-4031 in sinoatrial pacemaker cells

Author

Dokos, S. ; Boyett, M.R. ; Cloherty, S.L. ; Lovell, N.H.

Author_Institution

Graduate Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia

Volume

2

fYear

2002

fDate

2002

Firstpage

1345

Abstract

We have developed a new mathematical model of single cell rabbit sinoatrial node pacemaker activity, employing Markov state kinetic descriptions of ionic currents. Parameters of the model have been adjusted to match experimental recordings of free running action potentials from the periphery of the node, recorded both in the absence and presence of E-4031-a selective blocker of the rapid delayed rectifier K⁺ current (i_K,r). Results from the model suggest that the effects of E-4031 on action potential waveshape can be reproduced by simply lowering the membrane conductance of i_K,r.

Keywords

Markov processes; bioelectric potentials; biomembrane transport; cardiology; physiological models; potassium; E-4031; K⁺; K⁺ current; Markov state kinetic descriptions; action potential waveshape; cardiac action potentials; free running action potentials; ionic currents; mathematical model; membrane conductance; node periphery; pharmacological block modelling; rapid delayed rectifier current; selective blocker; single cell rabbit sinoatrial node pacemaker activity; sinoatrial pacemaker cells; Biomedical engineering; Biomembranes; Delay; Kinetic theory; Mathematical model; Pacemakers; Rabbits; Rectifiers; Storage area networks; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106420

Filename

1106420