Estimating brain compliance based on a novel model of intracranial cerebrospinal fluid dynamics

Author

Hu, X. ; Alwan, A.A. ; Nenov, V.I. ; Rubinstein, E.H. ; Bergsneider, M.

Author_Institution

Biomed. Eng. Program, California Univ., Los Angeles, CA, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

282

Abstract

The assumption that cerebrospinal fluid (CSF) inflow and outflow is an essential element of an intracranial compartment (IC) model has been recently questioned [M. Bergsneider, Neurosurg. Clin. N. Am., vol. 12, p. 631-8, 2001]. The idea proposed by Bergsneider that the free displacement of the CSF is one of the significant sources of the brain compliance is supported in this paper by computing an overall system compliance with a novel algorithm. The compliance obtained using the proposed method is shown to be in the same order of the magnitude as that obtained using the traditional intrusive infusion test technique.

Keywords

biological fluid dynamics; brain models; elasticity; CSF production rate; algorithm; brain compliance estimation; capacitor; cerebrospinal fluid inflow; cerebrospinal fluid outflow; hemodynamic consequences; intracranial cerebrospinal fluid dynamics; intracranial pressure; lumped model; outflow resistance; pulsatile arterial flow; rabbit experiments; traditional intrusive infusion test technique; venous flow; Biomedical engineering; Brain modeling; Circuit testing; Cranial pressure; Fluid dynamics; Immune system; In vivo; Integrated circuit modeling; Neurosurgery; Rabbits;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1134494

Filename

1134494