Compositional effects on albumin system properties

Author

Overby, R.J. ; Feldman, D.S.

Author_Institution

Dept. of Biomed. Eng., Alabama Univ., Birmingham, AL, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

809

Abstract

Previous studies have shown that tissue scaffold systems for wound healing enhancement can be created using albumin crosslinked with a functionalized polyethylene glycol. The overall properties of this scaffold system are dictated by compositional factors such as functional end chemistry and component ratio as well as environmental effects like pH. In this study, we investigated how changes in composition and environment will affect such system properties as swellability, cure time, and degradation in an effort to select the best scaffold system. Ultimately, scaffolds will be optimized for specific clinical applications.

Keywords

biochemistry; biological tissues; biomedical materials; curing; pH; patient treatment; polymer gels; proteins; swelling; albumin hydrogels; albumin system properties; component ratio; compositional effects; compositional factors; crosslinked albumin; cure time; degradation; environmental effects; functional end chemistry; functionalized polyethylene glycol; pH; specific clinical applications; swellability; tissue scaffold systems; wound healing enhancement; Analysis of variance; Biomedical engineering; Chemistry; Degradation; Dermis; In vivo; Polyethylene; Polymers; Tissue engineering; Wounds;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1137086

Filename

1137086