Cell Patterning Using Magnetic Concentric Rectangular Thin Films for Biochip Application

Author

Tzong-Rong Ger ; Chen-Yu Huang ; Chia-Wei Chiang ; Po-Wei Fu ; Keng-Shiang Hu ; Yi-Han Peng ; Zung-Hang Wei

Author_Institution

Dept. of Power Mech. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan

Volume

49

Issue

7

fYear

2013

fDate

Jul-13

Firstpage

3496

Lastpage

3499

Abstract

In this report, magnetic cell patterning is demonstrated through controlling the micromagnetic states in microstructured concentric rectangular ferromagnetic thin films. The number of magnetic nanoparticles entered the cells via endocytosis can be determined by magnetophoresis experiment. In concentric rectangular magnetic films, the effects of cell patterning differ from magnetic films at as-deposited state and at remnant states after applying field. Remnant states of concentric rectangular are proposed for cell patterning. Living cells can be arranged at specific diagonal direction in sequence by selectively changing the magnetic field directions.

Keywords

ferromagnetic materials; magnetic particles; magnetic thin films; remanence; biochip application; endocytosis; magnetic cell patterning; magnetic concentric rectangular ferromagnetic thin films; magnetic field; magnetic nanoparticles; magnetophoresis experiment; micromagnetic states; remnant states; Magnetic domain walls; Magnetic domains; Magnetic resonance imaging; Magnetosphere; Nanoparticles; Saturation magnetization; Substrates; Cell patterning; magnetic domain walls; magnetophoresis;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/TMAG.2013.2245866

Filename

6559051