Controlled ultrasound tissue erosion

Author

Xu, Zhen ; Ludomirsky, Achian ; Eun, Lucy Y. ; Hall, Timothy L. ; Tran, Binh C. ; Fowlkes, J. Brian ; Cain, Charles A.

Author_Institution

Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA

Volume

1

fYear

2003

fDate

5-8 Oct. 2003

Firstpage

732

Abstract

The ability of ultrasound to produce highly controlled tissue erosion was investigated. This study is motivated by the need to develop a noninvasive procedure to perforate the neonatal atrial septum in treatment of hypoplastic left heart syndrome. A total of 232 holes were generated in 40 pieces of porcine atrial wall by a 788 kHz single element transducer. The effects of various parameters (i.e. pulse repetition frequency (PRF), pulse duration (PD), gas content, and intensity) on erosion rate and energy efficiency were explored. PDs of 3, 6, 12 and 24 cycles, PRFs between 1.34 kHz and 66.7 kHz, gas saturation of 40-55% and 79-85%, and Isppa´s between 3000 W/cm² and 9000 w/cm²were applied. Results show that very short pulses delivered at an optimum PRF could be the most effective for controlled ultrasound tissue erosion. Results also show that the acoustic backscatter from the bubble cloud in the erosion zone is highly correlated with the erosion process.

Keywords

biological effects of acoustic radiation; biological tissues; bubbles; echocardiography; patient treatment; ultrasonic effects; 1.34 to 66.7 kHz; 788 kHz; PRF; acoustic backscatter; bubble cloud; erosion process; erosion rate; erosion zone; gas saturation; hypoplastic left heart syndrome; neonatal atrial septum; pulse duration; pulse repetition frequency; single element transducer; ultrasound tissue erosion; Cardiology; Energy efficiency; Frequency; Heart; In vitro; Medical treatment; Monitoring; Pediatrics; Ultrasonic imaging; Ultrasonic transducers;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics, 2003 IEEE Symposium on

Print_ISBN

0-7803-7922-5

Type

conf

DOI

10.1109/ULTSYM.2003.1293505

Filename

1293505