Modeling of systemic circulation and heat exchange in whole body hyperthermia (43-44/spl deg/C)

Many experimental and clinical trials showed a high efficacy of whole body hyperthermia (43-44/spl deg/C) (WBH) in treatment of malignant tumors and in some viral diseases including HIV/AIDS. However a widespread clinical application of WBH remains difficult due to poorly controlled circulation disturbances. The aim of current research is to describe structural connections between the organs during WBH (43-44/spl deg/C), and find the way to stabilize blood circulation. Current research formulates model requirements for blood circulation changes, and shows interconnections between the models of circulation and heat transfer. Potentialities of circuit theory allow measuring of some parameters (thermal capacity and thermal conductivity of organs) in the beginning of WBH procedure when circulation is stable. Results from the model allow predicting blood circulation disorder and their prevention when rising the body temperature over 42/spl deg/C. Thus it can be used for temperature calculation, increase of efficacy and safety of hyperthermia.